• • DRAMP ID

  • DRAMP01255

• • Peptide Name

  • Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)

• • Source

  • Rana dybowskii (Dybovsky's frog) (Korean brown frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • SAVGRHGRRFGLRKHRKH

• • Sequence Length

  • 18

• • UniProt Entry

  • B5A9T1

• • Protein Existence

  • Transcript level

• • SMILES

  • CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.19539775] Gram-negative bacterium:

      Target Organism	Activity
      Escherichia coli (MIC=3 µM);	-

    • Gram-negative bacterium:

      Target Organism	Activity
      Staphylococcus aureus	MIC=6 µM

    • [Ref.19341344] Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus	MIC=14.4 µM
      Bacillus cereus	MIC=14.4 µM
      Streptococcus lactis	MIC=14.4 µM

• • Hemolytic Activity

  • • [Ref:19539775]HC50>300 μM against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01255.

DRAMP01255

• • Function

  • Antimicrobial peptide. Has activity against the Gram-positive bacteria

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.

• • Pubmed ID

  • 19539775

• • Reference

  • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.

• • Author

  • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.

• ·Literature 2

• • Title

  • Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis.

• • Pubmed ID

  • 19341344

• • Reference

  • Zoolog Sci. 2009 Mar;26(3):220-226.

• • Author

  • Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y.