General Information

    • DRAMP ID

    • DRAMP01305

    • Peptide Name

    • Phylloseptin-7 (PS-7; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa hypochondrialis (Orange-legged leaf frog)

    • Family

    • Not found

    • Gene

    • psn7

    • Sequence

    • FLSLIPHAINAVSAIAKHFG

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](C)CC)[C@H](C)CC)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.16963159]Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coliMIC=6 µM
        Pseudomonas aeruginosa (MIC=6 µM);-
      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureusMIC=6 µM

    • Hemolytic Activity

      • [Ref:16963159]Non-hemolytic activity at 6 μM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01305.

Physicochemical Information

    • Formula

    • C100H156N26O24

    • Absent Amino Acids

    • CDEMQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 2106.5

    • PI

    • 8.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • 14.47

    • Hydrophobicity

    • 1.035

    • Aliphatic Index

    • 132

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01305

Comments Information

    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli and P. aeruginosa, and the Gram-positive bacteria

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.

    • Reference

    • Peptides. 2006 Dec;27(12):3092-3999.

    • Author

    • Conceição K, Konno K, Richardson M, Antoniazzi MM, Jared C, Daffre S, Camargo AC, Pimenta DC.
  • ·Literature 2

    • Title

    • Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis.

    • Reference

    • Peptides. 2006 Sep;27(9):2129-2136.

    • Author

    • Chen T, Zhou M, Gagliardo R, Walker B, Shaw C.