General Information
-
DRAMP ID
- DRAMP01317
-
Peptide Name
- Phylloseptin 15 (PS-15; Frogs, amphibians, animals)
-
Source
- Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
-
Family
- Not found
-
Gene
- psn15
-
Sequence
- LLSLVPHAINAVSAIAKHF
-
Sequence Length
- 19
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01317.
Physicochemical Information
-
Formula
- C94H153N25O23
Absent Amino Acids
- CDEGMQRTWY
Common Amino Acids
- A
Mass
- 2001.4
PI
- 8.76
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +3
-
Boman Index
- 14.59
Hydrophobicity
- 1.147
Aliphatic Index
- 154.21
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01317
Comments Information
Function
- Has antimicrobial activity (By similarity).
Tissue specificity
- Expressed by the skin glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
-
Title
- A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
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Pubmed ID
- 17553595
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Reference
- Peptides. 2007 Jul;28(7):1331-1343.
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Author
- Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.