General Information

    • DRAMP ID

    • DRAMP01365

    • Peptide Name

    • Maculatin-1.2 (Frogs, amphibians, animals)

    • Source

    • Litoria genimaculata (Green-eyed tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFGVLAKVASHVVPAIAEHFQA

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus, Streptococcus uberis.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01365 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01365.

Physicochemical Information

    • Formula

    • C111H173N29O28

    • Absent Amino Acids

    • CDMNRTWY

    • Common Amino Acids

    • A

    • Mass

    • 2361.77

    • PI

    • 6.92

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +2

    • Boman Index

    • 17.19

    • Hydrophobicity

    • 1

    • Aliphatic Index

    • 123.04

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01365

DRAMP01365 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against S. aureus and S. uberis.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.

    • Reference

    • J Pept Sci. 1998 Apr;4(2):111-115.

    • Author

    • Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.