General Information

    • DRAMP ID

    • DRAMP01368

    • Peptide Name

    • Maculatin-2.1 (Frogs, amphibians, animals)

    • Source

    • Litoria genimaculata (brown-spotted treefrog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFVDFLKKVAGTIANVVT

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=100 µg/ml), Micrococcus luteus (MIC=100 µg/ml), Staphylococcus aureus (MIC=100 µg/ml), Staphylococcus epidermidis (MIC=50 µg/ml), Streptococcus uberis (MIC=25 µg/ml). (Ref.2)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01368 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01368.

Physicochemical Information

    • Formula

    • C88H143N21O24

    • Absent Amino Acids

    • CEHMPQRSWY

    • Common Amino Acids

    • V

    • Mass

    • 1879.23

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 5.86

    • Hydrophobicity

    • 0.961

    • Aliphatic Index

    • 118.89

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01368

DRAMP01368 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against the Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • The maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1.

    • Reference

    • J Pept Sci. 1998 Apr;4(2):111-115.

    • Author

    • Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.
  • ·Literature 2

    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

    • Reference

    • Peptides. 2004; 25: 1035-1054.

    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.