General Information
-
DRAMP ID
- DRAMP01375
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Peptide Name
- Odorranain-E1 (OdE1; Frogs, amphibians, animals)
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Source
- Odorrana grahami (Yunnanfu frog) (Rana grahami)
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Family
- Not found
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Gene
- Not found
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Sequence
- GLGGAKKNFIIAANKTAPQSVKKTFSCKLYNG
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Sequence Length
- 32
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UniProt Entry
- A6MBK8
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Protein Existence
- Transcript level
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.17272268] Gram-negative bacterium: Escherichia coli (MIC=9.37 μg/ml);
- Gram-positive bacteria: Staphylococcus aureus (MIC=4.68 μg/ml), Bacillus subtilis (MIC=4.68 μg/ml).
- Yeast: Candida albicans (MIC=9.37 μg/ml).
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Hemolytic Activity
-
- [Ref:17272268]Non-hemolytic activity against rabbit red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Odorranain-E1 adopts 100% turn structure in water solution.
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- Please click DRAMP01375_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C151H248N42O42S
Absent Amino Acids
- DEHMRW
Common Amino Acids
- K
Mass
- 3355.95
PI
- 10.14
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +6
-
Boman Index
- -28.88
Hydrophobicity
- -0.275
Aliphatic Index
- 70.31
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 48.06
Polar Residues
- 13
DRAMP01375
Comments Information
Function
- Odorranain-E1 exhibites antimicrobial activities against all of the tested microbes including Gram-positive and Gram-negative bacteria and fungi. Has no hemolytic activity against red cell.
Literature Information
- ·Literature 1
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Title
- Anti-infection peptidomics of amphibian skin.
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Pubmed ID
- 17272268
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Reference
- Mol Cell Proteomics. 2007 May;6(5):882-894.
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Author
- Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.