General Information
-
DRAMP ID
- DRAMP01397
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Peptide Name
- Odorranain-F-OA2 (Frogs, amphibians, animals)
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Source
- Odorrana grahami (Yunnanfu frog)
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Family
- Not found
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Gene
- Not found
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Sequence
- GFMDTAKNVAKNMAVTLLDNLKCKITKAC
-
Sequence Length
- 29
-
UniProt Entry
- No entry found
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=7.5 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.5 µg/ml);
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=3.8 µg/ml);
- Yeast: Candida albicans ATCC 2002 (MIC=3.8 µg/ml).
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Hemolytic Activity
-
- [Ref:22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys23 and Cys29)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys23 and Cys29.
-
Stereochemistry
- L
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01397_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C135H233N37O40S4
Absent Amino Acids
- EHPQRSWY
Common Amino Acids
- K
Mass
- 3142.8
PI
- 9.24
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- -26.64
Hydrophobicity
- 0.124
Aliphatic Index
- 87.59
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.46
Polar Residues
- 9
DRAMP01397
Comments Information
Function
- Weakly active against bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.
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Pubmed ID
- 22029824
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Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
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Author
- Yang X, Lee WH, Zhang Y.