• DRAMP ID

    • DRAMP01417
    • Peptide Name

    • Nigrocin-2GRa (Frogs, amphibians, animals)
    • Source

    • Rana grahami (Asian frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLLSGILGAGKHIVCGLSGLC
    • Sequence Length

    • 21
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • [Ref.16621155]Gram-negative bacterium: Escherichia coli (MIC=25 µM).
    • Hemolytic Activity

      • [Ref:16621155] LC50=295 μM against human erythrocytes
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys15 and Cys21)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys15 and Cys21.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01417 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C86H150N24O24S2
    • Absent Amino Acids

    • DEFMNPQRTWY
    • Common Amino Acids

    • G
    • Mass

    • 1968.4
    • PI

    • 8.07
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 31.48
    • Hydrophobicity

    • 1.329
    • Aliphatic Index

    • 148.57
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.25
    • Polar Residues

    • 10

DRAMP01417

DRAMP01417 chydropathy plot
    • Function

    • Has antibacterial against Gram-negative bacterium E. coli. Also has a weak hemolytic activity against human erythrocytes.
  • ·Literature 1
    • Title

    • Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami.
    • Reference

    • Peptides. 2006 Sep;27(9):2111-2117.
    • Author

    • Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.