• DRAMP ID

    • DRAMP01421
    • Peptide Name

    • Nigrocin-OG5 (Frogs, amphibians, animals)
    • Source

    • Odorrana grahami (Yunnanfu frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLLSGILGAGKQKVCGLSGLC
    • Sequence Length

    • 21
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=9.37 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=18.75 µg/ml), Bacillus subtilis (MIC=37.50 µg/ml).
      • Yeast: Candida albicans (MIC=4.68 µg/ml).
    • Hemolytic Activity

      • [Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 μg/ml. RCH, red cell hemolysis.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys15 and Cys21)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys15 and Cys21.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01421 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C85H152N24O25S2
    • Absent Amino Acids

    • DEFHMNPRTWY
    • Common Amino Acids

    • G
    • Mass

    • 1974.41
    • PI

    • 8.9
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +2
    • Boman Index

    • 20.13
    • Hydrophobicity

    • 0.914
    • Aliphatic Index

    • 130
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.25
    • Polar Residues

    • 10

DRAMP01421

DRAMP01421 chydropathy plot
    • Function

    • Has antibacterial and antifungal activity.
  • ·Literature 1
    • Title

    • Anti-infection peptidomics of amphibian skin.
    • Reference

    • Mol Cell Proteomics. 2007 May;6(5):882-894.
    • Author

    • Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.