General Information
-
DRAMP ID
- DRAMP01460
-
Peptide Name
- Esculentin-2Vb (2VEb; Frogs, amphibians, animals)
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Source
- Odorrana versabilis (Chinese bamboo leaf odorous frog) (Rana versabilis)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- GLFSILKGVGKIAIKGLGKNLGKMGLDLVSCKISKEC
-
Sequence Length
- 37
-
UniProt Entry
- Q1JS89
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01460.
Physicochemical Information
-
Formula
- C171H301N45O46S3
Absent Amino Acids
- HPQRTWY
Common Amino Acids
- GK
Mass
- 3819.72
PI
- 9.7
Basic Residues
- 7
Acidic Residues
- 2
Hydrophobic Residues
- 14
Net Charge
- +5
-
Boman Index
- 2.34
Hydrophobicity
- 0.478
Aliphatic Index
- 123.78
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.47
Polar Residues
- 13
DRAMP01460
Comments Information
Function
- Antimicrobial peptide (By similarity).
Tissue specificity
- Expressed by the skin glands.
PTM
- Contains one disulfide bond 31-37.
Literature Information
- ·Literature 1
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Title
- The Chinese bamboo leaf odorous frog (Rana (Odorrana) versabilis) and North American Rana frogs share the same families of skin antimicrobial peptides.
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Pubmed ID
- 16621152
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Reference
- Peptides. 2006 Jul;27(7):1738-1744.
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Author
- Chen T, Zhou M, Rao P, Walker B, Shaw C.