General Information

    • DRAMP ID

    • DRAMP01463

    • Peptide Name

    • Esculentin-1SEa (Frogs, amphibians, animals)

    • Source

    • Rana sevosa (Dusky gopher frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSKFNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC

    • Sequence Length

    • 46

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli K12;
      • Gram-positive bacterium: Micrococcus luteus NCT C2665.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01463 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01463.

Physicochemical Information

    • Formula

    • C221H384N60O60S2

    • Absent Amino Acids

    • HMPQWY

    • Common Amino Acids

    • K

    • Mass

    • 4905.97

    • PI

    • 9.87

    • Basic Residues

    • 11

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +7

    • Boman Index

    • -39.46

    • Hydrophobicity

    • 0.002

    • Aliphatic Index

    • 106.09

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 14

DRAMP01463

DRAMP01463 chydropathy plot

Comments Information

    • Function

    • Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro. Has antibacterial activity.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • Problely contains one dislfide bond 40-46.

Literature Information

  • ·Literature 1

    • Title

    • Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa.

    • Reference

    • Peptides. 2006 Jun;27(6):1313-1319.

    • Author

    • Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C.