• DRAMP ID

    • DRAMP01477
    • Peptide Name

    • Esculentin-1HSa (Frogs, amphibians, animals)
    • Source

    • Rana hosii (Hose's rock frog) (Odorrana hosii)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC
    • Sequence Length

    • 46
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=12 µM);
      • Gram-negative bacterium: Escherichia coli ATCC 25726 (MIC=12 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01477 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C215H361N59O59S3
    • Absent Amino Acids

    • HPQWY
    • Common Amino Acids

    • G
    • Mass

    • 4812.77
    • PI

    • 9.63
    • Basic Residues

    • 9
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +5
    • Boman Index

    • -30.41
    • Hydrophobicity

    • 0.148
    • Aliphatic Index

    • 93.26
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 2.78
    • Polar Residues

    • 15

DRAMP01477

DRAMP01477 chydropathy plot
    • Function

    • Has antibacterial activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • contains one disulfide bond 40-46.
  • ·Literature 1
    • Title

    • Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
    • Reference

    • Toxicon. 2008 Sep 1;52(3):465-473.
    • Author

    • Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, King JD.