General Information
-
DRAMP ID
- DRAMP01539
-
Peptide Name
- Nigroain-C2 (Frogs, amphibians, animals)
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Source
- Rana nigrovittata (Black-striped frog)
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Family
- Not found
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Gene
- Not found
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Sequence
- FKTWKRPPFQTSCWGIIKE
-
Sequence Length
- 19
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UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 µg/ml), S. aureus ATCC43300 (MIC=55.00 µg/ml), Bacillus subtilis (MIC=110.00 µg/ml);
- Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 µg/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 µg/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 µg/ml).
- Yeast: Candida albicans ATCC2002 (MIC=13.75 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01539_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C112H166N28O26S
Absent Amino Acids
- ADHLMNVY
Common Amino Acids
- K
Mass
- 2352.78
PI
- 9.79
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +3
-
Boman Index
- -29.78
Hydrophobicity
- -0.721
Aliphatic Index
- 41.05
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 611.11
Polar Residues
- 5
DRAMP01539
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.
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Pubmed ID
- 19778602
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Reference
- Genomics. 2010 Jan;95(1):66-71.
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Author
- Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.