General Information

    • DRAMP ID

    • DRAMP01539

    • Peptide Name

    • Nigroain-C2 (Frogs, amphibians, animals)

    • Source

    • Rana nigrovittata (Black-striped frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKTWKRPPFQTSCWGIIKE

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus ATCC25923MIC=27.50 µg/ml
        S. aureus ATCC43300MIC=55.00 µg/ml
        Bacillus subtilis (MIC=110.00 µg/ml);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ML-35PMIC=110.00 µg/ml
        Pseudomonas aeruginosa PA01MIC=55.00 µg/ml
        Pseudomonas aeruginosa ATCC27853MIC=55.00 µg/ml
      • Yeast:
        Target OrganismActivity
        Candida albicans ATCC2002MIC=13.75 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01539.

Physicochemical Information

    • Formula

    • C112H166N28O26S

    • Absent Amino Acids

    • ADHLMNVY

    • Common Amino Acids

    • K

    • Mass

    • 2352.78

    • PI

    • 9.79

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -29.78

    • Hydrophobicity

    • -0.721

    • Aliphatic Index

    • 41.05

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 611.11

    • Polar Residues

    • 5

DRAMP01539

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.

    • Reference

    • Genomics. 2010 Jan;95(1):66-71.

    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.