General Information

    • DRAMP ID

    • DRAMP01543

    • Peptide Name

    • Nigroain-E1 (Frogs, amphibians, animals)

    • Source

    • Rana nigrovittata (Black-striped frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DCTRWIIGINGRICRD

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • [Ref.19778602]Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=18.75 µg/ml);
      • Yeast: Candida albicans ATCC2002 (MIC=75 µg/ml).

    • Hemolytic Activity

      • [Ref:19778602]7.62±1.6% hemolytic activity at 100 µg/ml against rabbit red cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bridge between Cys2 and Cys14.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01543 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01543.

Physicochemical Information

    • Formula

    • C79H131N27O23S2

    • Absent Amino Acids

    • AEFHKLMPQSVY

    • Common Amino Acids

    • I

    • Mass

    • 1891.2

    • PI

    • 8.07

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +1

    • Boman Index

    • -44.96

    • Hydrophobicity

    • -0.213

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 375

    • Polar Residues

    • 6

DRAMP01543

Comments Information

    • Function

    • Has hemolytic activity against rabbit red cells.

Literature Information

  • ·Literature 1

    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.

    • Reference

    • Genomics. 2010 Jan;95(1):66-71.

    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.