General Information

    • DRAMP ID

    • DRAMP01594

    • Peptide Name

    • Citropin-1.2 (Frogs, amphibians, animals)

    • Source

    • Litoria citropa (Australian blue mountains tree frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDIIKKVASVVGGL

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=25 µg/ml), Leuconostoc lactis (MIC=3 µg/ml), Listeria innocua (MIC=100 µg/ml), Micrococcus luteus (MIC=12 µg/ml), Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus epidermidis (MIC=25 µg/ml), Streptococcus uberis (MIC=12 µg/ml). (Ref.2)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01594 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01594.

Physicochemical Information

    • Formula

    • C76H130N18O20

    • Absent Amino Acids

    • CEHMNPQRTWY

    • Common Amino Acids

    • GV

    • Mass

    • 1615.98

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 16.19

    • Hydrophobicity

    • 1.281

    • Aliphatic Index

    • 158.13

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01594

Comments Information

    • Function

    • Amphibian defensive peptide.

    • Tissue specificity

    • Expressed by the dorsal and submental skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.

    • Reference

    • Eur J Biochem. 1999 Oct;265(2):627-637.

    • Author

    • Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.
  • ·Literature 2

    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

    • Reference

    • Peptides. 2004 Jun;25(6):1035-1054.

    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.