General Information
-
DRAMP ID
- DRAMP01601
-
Peptide Name
- Citropin-2.1 (Frogs, amphibians, animals)
-
Source
- Litoria citropa (Australian blue mountains tree frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLIGSIGKALGGLLVDVLKPKL
-
Sequence Length
- 22
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacterium: Leuconostoc lactis (MIC=50 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01601.
Physicochemical Information
-
Formula
- C101H181N25O26
Absent Amino Acids
- CEFHMNQRTWY
Common Amino Acids
- L
Mass
- 2161.7
PI
- 9.7
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- 25.18
Hydrophobicity
- 1.018
Aliphatic Index
- 172.73
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01601
Comments Information
Function
- Amphibian defensive peptide.
Tissue specificity
- Expressed by the dorsal and submental skin glands.
Literature Information
- ·Literature 1
-
Title
- Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.
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Pubmed ID
- 10504394
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Reference
- Eur J Biochem. 1999 Oct;265(2):627-637.
-
Author
- Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.