General Information

    • DRAMP ID

    • DRAMP01606

    • Peptide Name

    • Aurein-1.1 (Frogs, amphibians, animals)

    • Source

    • Litoria raniformis (Southern bell frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDIIKKIAESI

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=50 µg/ml), Lactococcus lactis (MIC=25 µg/ml), Listeria innocua (MIC=100 µg/ml), Streptococcus uberis (MIC=100 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01606 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01606.

Physicochemical Information

    • Formula

    • C68H115N15O19

    • Absent Amino Acids

    • CHMNPQRTVWY

    • Common Amino Acids

    • I

    • Mass

    • 1446.75

    • PI

    • 6.07

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • 0

    • Boman Index

    • 0.3

    • Hydrophobicity

    • 0.8

    • Aliphatic Index

    • 157.69

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01606

Comments Information

    • Function

    • The aurein antibiotics show more activity towards gram-positive than gram-negative pathogens. Probably acts by disturbing membrane functions with its amphipathic structure. Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

    • Reference

    • Eur J Biochem. 2000 Sep;267(17):5330-5341.

    • Author

    • Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.