• DRAMP ID

    • DRAMP01615
    • Peptide Name

    • Aurein-3.1.1 (Frogs, amphibians, animals)
    • Source

    • Litoria aurea (Green and golden bell frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLFDIVKKIAGHIA
    • Sequence Length

    • 14
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-cancer
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01615 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01615.
    • Formula

    • C70H116N18O17
    • Absent Amino Acids

    • CEMNPQRSTWY
    • Common Amino Acids

    • I
    • Mass

    • 1481.8
    • PI

    • 8.6
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +2
    • Boman Index

    • 7.72
    • Hydrophobicity

    • 0.9
    • Aliphatic Index

    • 146.43
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01615

    • Function

    • Has antimicrobial activity against L.lactis, L.innocua, M.luteus, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.
  • ·Literature 1
    • Title

    • The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
    • Reference

    • Eur J Biochem. 2000 Sep;267(17):5330-5341.
    • Author

    • Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.