General Information

    • DRAMP ID

    • DRAMP01619

    • Peptide Name

    • Aurein-3.3.1 (Frogs, amphibians, animals)

    • Source

    • Litoria raniformis (Southern bell frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FDIVKKIAGHIVSSI

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-cancer

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01619 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01619.

Physicochemical Information

    • Formula

    • C76H127N19O20

    • Absent Amino Acids

    • CELMNPQRTWY

    • Common Amino Acids

    • I

    • Mass

    • 1626.96

    • PI

    • 8.6

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 2.21

    • Hydrophobicity

    • 0.967

    • Aliphatic Index

    • 149.33

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01619

Comments Information

    • Function

    • Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Literature Information

  • ·Literature 1

    • Title

    • The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

    • Reference

    • Eur J Biochem. 2000 Sep;267(17):5330-5341.

    • Author

    • Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.