• • DRAMP ID

  • DRAMP01621

• • Peptide Name

  • Bombinin-H1 (Frogs, amphibians, animals)

• • Source

  • Bombina variegata (European frog)

• • Family

  • Belongs to the bombinin family

• • Gene

  • Not found

• • Sequence

  • IIGPVLGMVGSALGGLLKKI

• • Sequence Length

  • 20

• • UniProt Entry

  • P82282,P82283

• • Protein Existence

  • Protein level

• • SMILES

  • CC[C@@H](C)[C@H](N)C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)[C@H](C)CC)C(C)C)C(C)C)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.8223491]Gram-negative bacterium:

      Target Organism	Activity
      Escherichia coli D21 (MIC=3.8 µM);	-

    • Gram-positive bacterium:

      Target Organism	Activity
      Staphylococcus aureus Cowan 1	MIC=2.1 µM

• • Hemolytic Activity

  • • [Ref:8223491]Not determined hemolytic activity against human red blood cells.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01621_predicted_structure.pdb to download.

DRAMP01621

• • Function

  • Has antimicrobial.

• • Tissue specificity

  • Expressed by the skin glands.

• • PTM

  • C-terminal amidation and D-amino acid.

• ·Literature 1

• • Title

  • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

• • Pubmed ID

  • 8223491

• • Reference

  • EMBO J. 1993 Dec;12(12):4829-4832.

• • Author

  • Mignogna G, Simmaco M, Kreil G, Barra D.