General Information

    • DRAMP ID

    • DRAMP01652

    • Peptide Name

    • Dermaseptin-B5 (Dermaseptin BV; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLWNKIKEAASKAAGKAALGFVNEMV

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01652 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01652.

Physicochemical Information

    • Formula

    • C122H199N33O34S

    • Absent Amino Acids

    • CDHPQRTY

    • Common Amino Acids

    • A

    • Mass

    • 2704.18

    • PI

    • 9.53

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • -8.32

    • Hydrophobicity

    • 0.135

    • Aliphatic Index

    • 90.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 220

    • Polar Residues

    • 6

DRAMP01652

DRAMP01652 chydropathy plot

Comments Information

    • Function

    • Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation (Potential).

Literature Information

  • ·Literature 1

    • Title

    • Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics.

    • Reference

    • J Biol Chem. 1998 Jun 12;273(24):14690-7.

    • Author

    • Charpentier S, Amiche M, Mester J, Vouille V, Le Caer JP, Nicolas P, Delfour A.