General Information

    • DRAMP ID

    • DRAMP01656

    • Peptide Name

    • Dermaseptin DRG2 (Dermaseptin-2; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • DRG2

    • Sequence

    • RGLWSKIKEAGKAALTAAGKAALGAVSDAV

    • Sequence Length

    • 30

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01656 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01656.

Physicochemical Information

    • Formula

    • C129H220N38O38

    • Absent Amino Acids

    • CFHMNPQY

    • Common Amino Acids

    • A

    • Mass

    • 2911.4

    • PI

    • 10

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +3

    • Boman Index

    • -11.88

    • Hydrophobicity

    • 0.287

    • Aliphatic Index

    • 101.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 189.66

    • Polar Residues

    • 7

DRAMP01656

DRAMP01656 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity (Potential).

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Unknown

    • Reference

    • Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases

    • Author

    • Amiche M.