General Information
-
DRAMP ID
- DRAMP01672
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Peptide Name
- Dermaseptin-5 (DS V; Dermaseptin-S5, DS5; Frogs, amphibians, animals)
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Source
- Phyllomedusa sauvagei (Sauvage's leaf frog)
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Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
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Gene
- Not found
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Sequence
- GLWSKIKTAGKSVAKAAAKAAVKAVTNAV
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Sequence Length
- 29
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UniProt Entry
- P80281
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- [Swiss_Prot Entry P80281]Possesses a potent antimicrobial activity against bacteria, fungi and protozoa
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Hemolytic Activity
-
- [Ref:8306981]Show strong hemolytic activity against rabbit healthy erythrocytes
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01672.
Physicochemical Information
-
Formula
- C128H223N37O35
Absent Amino Acids
- CDEFHMPQRY
Common Amino Acids
- A
Mass
- 2840.41
PI
- 10.7
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 16
Net Charge
- +6
-
Boman Index
- -5.38
Hydrophobicity
- 0.335
Aliphatic Index
- 97.93
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 196.43
Polar Residues
- 7
DRAMP01672
Comments Information
MOA
- Probably acts by disturbing membrane functions with its amphipathic structure. Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity. Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite.
Pharmaceutical use
- Derivatives of this peptide may be used as therapeutic agents to treat bacterial infections and malaria, and to prevent infection by herpes simplex virus type 1 and HIV-1.
Literature Information
- ·Literature 1
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Title
- Isolation and structure of novel defensive peptides from frog skin.
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Pubmed ID
- 8306981
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Reference
- Eur J Biochem. 1994 Jan 15;219(1-2):145-154.
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Author
- Mor A, Nicolas P.