General Information
-
DRAMP ID
- DRAMP01675
-
Peptide Name
- Dermaseptin-3 (DStar 03; Frogs, amphibians, animals)
-
Source
- Phyllomedusa tarsius (Brownbelly leaf frog)
-
Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
-
Gene
- Not found
-
Sequence
- GLFKTLIKGAGKMLGHVAKQFLGSQGQPES
-
Sequence Length
- 30
-
UniProt Entry
- P84923
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
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Target Organism
-
- [Swiss_Prot Entry P84923]Gram-positive bacteria: Staphylococcus aureus, Enterococcus faecalis;
- Gram-neagtive bacterium: Pseudomonas aeruginosa;
- Fungi: Candida albicans and Paracoccidioides brasiliensis.
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Hemolytic Activity
-
- [Ref:PubMed ID is not available]100% hemolytic activity at 128 µg/ml
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01675.
Physicochemical Information
-
Formula
- C141H231N39O39S
Absent Amino Acids
- CDNRWY
Common Amino Acids
- G
Mass
- 3128.68
PI
- 10
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 10
Net Charge
- +4
-
Boman Index
- -13.45
Hydrophobicity
- -0.137
Aliphatic Index
- 81.33
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 9
DRAMP01675
Comments Information
Function
- Antimicrobial peptide, active against the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli and P. aeruginosa, and the yeasts C. albicans and P. brasiliensis. Has hemolytic activity.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Dermaseptins and phylloseptins from Phyllomedusa tarsius (Amphibia).
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Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (AUG-2006) to UniProtKB.
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Author
- Prates M.V, Jardim D.P, Silva L.P, Gordo M, Leite J.R.S.A, Figueredo R.C.R, Amaral A.C, Felipe M.S.S, Bloch C. Jr.