• • DRAMP ID

  • DRAMP01678

• • Peptide Name

  • Dermaseptin-6 (DStar 06; Frogs, amphibians, animals)

• • Source

  • Phyllomedusa tarsius (Brownbelly leaf frog)

• • Family

  • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

• • Gene

  • Not found

• • Sequence

  • ALWKNMLKGIGKLAGQAALGAVKTLVGA

• • Sequence Length

  • 28

• • UniProt Entry

  • P84926

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • [Swiss_Prot Entry P84926]Gram-positive bacteria: Staphylococcus aureus, Enterococcus faecalis;
    • Gram-neagtive bacterium: Pseudomonas aeruginosa.

• • Hemolytic Activity

  • • [Ref:PubMed ID is not available]Show hemolytic activity at 612 µM

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01678.

DRAMP01678

• • Function

  • Antimicrobial peptide, active against the Gram-positive bacterium S. aureus, and the Gram-negative bacteria E. coli and P. aeruginosa. Has hemolytic activity.

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Dermaseptins and phylloseptins from Phyllomedusa tarsius (Amphibia).

• • Pubmed ID

  • PubMed ID is not available

• • Reference

  • Submitted (AUG-2006) to UniProtKB.

• • Author

  • Prates M.V, Jardim D.P, Silva L.P, Gordo M, Leite J.R.S.A, Figueredo R.C.R, Amaral A.C, Felipe M.S.S, Bloch C. Jr.