General Information

    • DRAMP ID

    • DRAMP01680

    • Peptide Name

    • Dermaseptin-8 (DStar 08; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa tarsius (Brownbelly leaf frog)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • SLRGFLKGVGTALAGVGKVVADQFDKLLQAGQ

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Swiss_Prot Entry P84928]Gram-positive bacteria: Staphylococcus aureus;
      • Gram-neagtive bacterium: Escherichia coli.

    • Hemolytic Activity

      • [Ref:PubMed ID is not available]Show hemolytic activity at 432 µM

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01680 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01680.

Physicochemical Information

    • Formula

    • C146H243N41O42

    • Absent Amino Acids

    • CEHIMNPWY

    • Common Amino Acids

    • G

    • Mass

    • 3244.78

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +2

    • Boman Index

    • -12

    • Hydrophobicity

    • 0.344

    • Aliphatic Index

    • 109.69

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01680

DRAMP01680 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacterium S. aureus, and the Gram-negative bacteriun E. coli. Has hemolytic activity.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Dermaseptins and phylloseptins from Phyllomedusa tarsius (Amphibia).

    • Reference

    • Submitted (AUG-2006) to UniProtKB.

    • Author

    • Prates M.V, Jardim D.P, Silva L.P, Gordo M, Leite J.R.S.A, Figueredo R.C.R, Amaral A.C, Felipe M.S.S, Bloch C. Jr.