General Information
-
DRAMP ID
- DRAMP01686
-
Peptide Name
- Dermaseptin AA-1-1 (Frogs, amphibians, animals)
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Source
- Agalychnis annae (Blue-sided leaf frog)
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Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
-
Gene
- Not found
-
Sequence
- SLGSFMKGVGKGLATVGKIVADQFGKLLEA
-
Sequence Length
- 30
-
UniProt Entry
- O93221
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01686.
Physicochemical Information
-
Formula
- C137H229N35O39S
Absent Amino Acids
- CHNPRWY
Common Amino Acids
- G
Mass
- 3022.6
PI
- 9.52
Basic Residues
- 4
Acidic Residues
- 2
Hydrophobic Residues
- 13
Net Charge
- +2
-
Boman Index
- 3.46
Hydrophobicity
- 0.48
Aliphatic Index
- 104
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 9
DRAMP01686
Comments Information
MOA
- Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).
Literature Information
- ·Literature 1
-
Title
- Cloning of cDNAs encoding new peptides of the dermaseptin-family.
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Pubmed ID
- 9774745
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Reference
- Biochim Biophys Acta. 1998 Oct 14;1388(1):279-283.
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Author
- Wechselberger C.