General Information

    • DRAMP ID

    • DRAMP01695

    • Peptide Name

    • Dermaseptin PD-3-6 (Plasticin-DA1; Frogs, amphibians, animals)

    • Source

    • Pachymedusa dacnicolor (Giant mexican leaf frog)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • GVVTDLLNTAGGLLGNLVGSLSG

    • Sequence Length

    • 23

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01695 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01695.

Physicochemical Information

    • Formula

    • C92H159N25O32

    • Absent Amino Acids

    • CEFHIKMPQRWY

    • Common Amino Acids

    • GL

    • Mass

    • 2127.42

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • -1

    • Boman Index

    • 15.15

    • Hydrophobicity

    • 0.926

    • Aliphatic Index

    • 143.91

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 12

DRAMP01695

DRAMP01695 chydropathy plot

Comments Information

    • MOA

    • Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Cloning of cDNAs encoding new peptides of the dermaseptin-family.

    • Reference

    • Biochim Biophys Acta. 1998 Oct 14;1388(1):279-283.

    • Author

    • Wechselberger C.