General Information
-
DRAMP ID
- DRAMP01696
-
Peptide Name
- Dermaseptin PD-3-7 (Frogs, amphibians, animals)
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Source
- Pachymedusa dacnicolor (Giant mexican leaf frog)
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Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
-
Gene
- Not found
-
Sequence
- LLGDLLGQTSKLVNDLTDTVGSIV
-
Sequence Length
- 24
-
UniProt Entry
- O93455
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01696.
Physicochemical Information
-
Formula
- C108H187N27O38
Absent Amino Acids
- ACEFHMPRWY
Common Amino Acids
- L
Mass
- 2471.83
PI
- 3.93
Basic Residues
- 1
Acidic Residues
- 3
Hydrophobic Residues
- 10
Net Charge
- -2
-
Boman Index
- -9.02
Hydrophobicity
- 0.567
Aliphatic Index
- 150
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 9
DRAMP01696
Comments Information
MOA
- Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).
Literature Information
- ·Literature 1
-
Title
- Cloning of cDNAs encoding new peptides of the dermaseptin-family.
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Pubmed ID
- 9774745
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Reference
- Biochim Biophys Acta. 1998 Oct 14;1388(1):279-283.
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Author
- Wechselberger C.