General Information

    • DRAMP ID

    • DRAMP01699

    • Peptide Name

    • Dermaseptin-H2 (Dermaseptin-like peptide 2, DMS2; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLWSKIKDVAAAAGKAALGAVNEALGEQ

    • Sequence Length

    • 28

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01699 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01699.

Physicochemical Information

    • Formula

    • C121H200N34O38

    • Absent Amino Acids

    • CFHMPRTY

    • Common Amino Acids

    • A

    • Mass

    • 2739.12

    • PI

    • 6.18

    • Basic Residues

    • 3

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 15

    • Net Charge

    • 0

    • Boman Index

    • -6.24

    • Hydrophobicity

    • 0.221

    • Aliphatic Index

    • 105

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 203.7

    • Polar Residues

    • 6

DRAMP01699

DRAMP01699 chydropathy plot

Comments Information

    • MOA

    • Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • A genomic/proteomic approach to isolating and identifying bioactive peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Thesis (2006), University of Ulster Coleraine, United Kingdom.

    • Author

    • Thompson A.H.