General Information

    • DRAMP ID

    • DRAMP01702

    • Peptide Name

    • Dermaseptin-H5 (Dermaseptin-like peptide 5, DMS5; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLWSTIKNVGKEAAIAAGKAVLGSL

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coliEscherichia coli ATCC 11775 (MIC=0.5 µM);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (MIC=0.5 µM), Micrococcus luteus ATCC 49732 (MIC=2.0 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01702 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01702.

Physicochemical Information

    • Formula

    • C111H188N30O32

    • Absent Amino Acids

    • CDFHMPQRY

    • Common Amino Acids

    • A

    • Mass

    • 2454.9

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • 8.35

    • Hydrophobicity

    • 0.572

    • Aliphatic Index

    • 121.2

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 8

DRAMP01702

DRAMP01702 chydropathy plot

Comments Information

    • MOA

    • Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Peptides. 2007 Jul;28(7):1331-1343.

    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.