General Information

    • DRAMP ID

    • DRAMP01717

    • Peptide Name

    • Dermatoxin (Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • DRT

    • Sequence

    • SLGSFLKGVGTTLASVGKVVSDQFGKLLQAGQ

    • Sequence Length

    • 32

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Bacillus megaterium, Corynebacterium glutamicumm, Staphylococcus aureus (++);
      • Gram-negative bacteria: mollicutes Acholeplasma laidlawii, Spiroplasma melliferum (++); Burkholderia cepacia, Pseudomonas aeruginosa, Salmonella typhimurium and S. meliloti (+).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01717 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01717.

Physicochemical Information

    • Formula

    • C143H238N38O44

    • Absent Amino Acids

    • CEHIMNPRWY

    • Common Amino Acids

    • G

    • Mass

    • 3193.69

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • -4.75

    • Hydrophobicity

    • 0.384

    • Aliphatic Index

    • 103.44

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 12

DRAMP01717

DRAMP01717 chydropathy plot

Comments Information

    • Function

    • Possesses a potent antimicrobial activity against Gram-positive bacteria and less active against Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.

    • Tissue specificity

    • Highest expression in skin and to a lesser extent in brain and intestine.

    • Miscellaneous

    • The sequence shown corresponds to the dermatoxin isolated from frog skin. A variant of it is present in frog brain.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of dermatoxin from frog skin, an antibacterial peptide encoded by a novel member of the dermaseptin genes family.

    • Reference

    • Eur J Biochem. 2000 Jul;267(14):4583-4592.

    • Author

    • Amiche M, Seon AA, Wroblewski H, Nicolas P.