General Information
-
DRAMP ID
- DRAMP01738
-
Peptide Name
- Temporin-ALk (Frogs, amphibians, animals)
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Source
- Amolops loloensis
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FFPIVGKLLS
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Sequence Length
- 10
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UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.19843479]Gram-positive bacterium: Staphylococcus aureus ATCC2592 (MIC=15 µg/mL);
- Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 µg/mL), Bacillus dysenteriae (MIC=60 µg/mL), Acinetobacter calcoaceticus (MIC=75 µg/mL), Psecdomonas aeruginosa (MIC=25 µg/mL);
- Yeast: Candida albicans ATCC2002 (MIC=15 µg/mL).
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Hemolytic Activity
-
- [Ref:19843479]25% hemolytic activity at 100 μg/mL against rabbit red blood cells.
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01738.
Physicochemical Information
-
Formula
- C57H89N11O12
Absent Amino Acids
- ACDEHMNQRTWY
Common Amino Acids
- FL
Mass
- 1120.4
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +1
-
Boman Index
- 16.75
Hydrophobicity
- 1.52
Aliphatic Index
- 146
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP01738
Comments Information
Function
- Temporin-ALk exhibits hemolytic activity against rabbit red blood cells.
Literature Information
- ·Literature 1
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Title
- Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.
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Pubmed ID
- 19843479
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Reference
- Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.
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Author
- Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R.