• DRAMP ID

    • DRAMP01750
    • Peptide Name

    • Temporin-1PLa (Frogs, amphibians, animals)
    • Source

    • Rana palustris (pickerel frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPLVGKILSGLI
    • Sequence Length

    • 13
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=70 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01750 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01750.
    • Formula

    • C68H116N14O15
    • Absent Amino Acids

    • ACDEHMNQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 1369.75
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +1
    • Boman Index

    • 29.47
    • Hydrophobicity

    • 1.854
    • Aliphatic Index

    • 202.31
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01750

    • Function

    • Antimicrobial activity against the Gram-positive bacteria
  • ·Literature 1
    • Title

    • Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris.
    • Reference

    • Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105.
    • Author

    • Basir YJ, Knoop FC, Dulka J, Conlon JM.