• DRAMP ID

    • DRAMP01751
    • Peptide Name

    • Temporin-LT1 (Frogs, amphibians, animals)
    • Source

    • Hylarana latouchii
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPGLIAGIAKML
    • Sequence Length

    • 13
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • [Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 µM), Bacillus subtilis (MIC=25 µM).
    • Hemolytic Activity

      • [Ref:19340924]LD50>100 µg/ml against rabbit red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01751 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01751.
    • Formula

    • C65H110N14O14S
    • Absent Amino Acids

    • CDEHNQRSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1343.73
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +1
    • Boman Index

    • 29.88
    • Hydrophobicity

    • 1.723
    • Aliphatic Index

    • 165.38
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01751

    • Function

    • Temporin-LT1 shows hemolytic activities against rabbit red blood cells (LD50>100 µg/ml).
  • ·Literature 1
    • Title

    • Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae).
    • Reference

    • Biochimie. 2009 Apr;91(4):540-547.
    • Author

    • Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J.