General Information

    • DRAMP ID

    • DRAMP01752

    • Peptide Name

    • Temporin-LT2 (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPIALKALGSIFPKIL

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 µM), Bacillus subtilis (MIC=50 µM).

    • Hemolytic Activity

      • [Ref:19340924]LD50>200 µg/ml against rabbit red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01752 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01752.

Physicochemical Information

    • Formula

    • C93H153N19O19

    • Absent Amino Acids

    • CDEHMNQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1841.35

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 30.46

    • Hydrophobicity

    • 1.512

    • Aliphatic Index

    • 172.35

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01752

Comments Information

    • Function

    • Temporin-LT2 shows hemolytic activities against rabbit red blood cells (LD50>200 µg/ml).

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae).

    • Reference

    • Biochimie. 2009 Apr;91(4):540-547.

    • Author

    • Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J.