General Information

    • DRAMP ID

    • DRAMP01824

    • Peptide Name

    • Temporin-1Ja (Frogs, amphibians, animals)

    • Source

    • Rana japonica (Japanese reddish frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • ILPLVGNLLNDLL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

    • SMILES

    • Not available

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli;-
      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus-

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01824.

Physicochemical Information

    • Formula

    • C66H115N15O18

    • Absent Amino Acids

    • ACEFHKMQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 1406.73

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -1

    • Boman Index

    • 17.42

    • Hydrophobicity

    • 1.462

    • Aliphatic Index

    • 232.31

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01824

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria E. coli and the Gram-positive bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.

    • Reference

    • Peptides. 2002 Mar;23(3):419-425.

    • Author

    • Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM.