General Information
-
DRAMP ID
- DRAMP01881
-
Peptide Name
- Brevinin-2LTc (Frogs, amphibians, animals)
-
Source
- Hylarana latouchii (Broad-folded frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GVLDTFKDVAIGVAKGAGTGVLKALLCKLDKSC
-
Sequence Length
- 33
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=60 µM), Rhodococcus rhodochrous X15 (MIC=30 µM);
- Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=15 µM).
-
Hemolytic Activity
-
- [Ref.22426384] LD50>480 μM against human erythrocytes
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys27 and Cys33)
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys27 and Cys33.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01881.
Physicochemical Information
-
Formula
- C146H252N38O43S2
Absent Amino Acids
- EHMNPQRWY
Common Amino Acids
- GKL
Mass
- 3291.96
PI
- 8.79
Basic Residues
- 5
Acidic Residues
- 3
Hydrophobic Residues
- 15
Net Charge
- +2
-
Boman Index
- 0.71
Hydrophobicity
- 0.639
Aliphatic Index
- 118.18
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.91
Polar Residues
- 10
DRAMP01881
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
-
Pubmed ID
- 22426384
-
Reference
- Biochimie. 2012 Jun;94(6):1317-1326.
-
Author
- Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.