General Information
-
DRAMP ID
- DRAMP01929
-
Peptide Name
- Brevinin-2Ec (Frogs, amphibians, animals)
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Source
- Rana esculenta (Edible frog) (Pelophylax esculentus) (Rana saharica (Sahara frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GILLDKLKNFAKTAGKGVLQSLLNTASCKLSGQC
-
Sequence Length
- 34
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
- [Swiss_Prot Entry P40839]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
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Hemolytic Activity
-
- [Ref.8163497]LC50>100 µM against human erythrocytes
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01929.
Physicochemical Information
-
Formula
- C154H267N43O46S2
Absent Amino Acids
- EHMPRWY
Common Amino Acids
- L
Mass
- 3521.19
PI
- 9.6
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 13
Net Charge
- +4
-
Boman Index
- -18.04
Hydrophobicity
- 0.179
Aliphatic Index
- 109.12
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.79
Polar Residues
- 13
DRAMP01929
Comments Information
Function
- Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity
Literature Information
- ·Literature 1
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Title
- Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
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Pubmed ID
- 8163497
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Reference
- J Biol Chem. 1994 Apr 22;269(16):11956-11961.
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Author
- Simmaco M, Mignogna G, Barra D, Bossa F.
- ·Literature 2
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Title
- Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity.
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Pubmed ID
- 16394170
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Reference
- J Endocrinol. 2006 Jan;188(1):1-9.
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Author
- Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH.