General Information

    • DRAMP ID

    • DRAMP01930

    • Peptide Name

    • Brevinin-1Ed (Frogs, amphibians, animals)

    • Source

    • Rana esculenta (Korea)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • VIPFVASVAAEMMHHVYCAASKRC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01930 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01930.

Physicochemical Information

    • Formula

    • C115H182N32O30S4

    • Absent Amino Acids

    • DGLNQTW

    • Common Amino Acids

    • A

    • Mass

    • 2621.15

    • PI

    • 8.04

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -3.17

    • Hydrophobicity

    • 0.796

    • Aliphatic Index

    • 85.42

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 70.22

    • Polar Residues

    • 5

DRAMP01930

DRAMP01930 chydropathy plot

Comments Information

    • This is a narrow spectrum AMP from the frog.

Literature Information

  • ·Literature 1

    • Title

    • Structure-activity relationships of antimicrobial peptides from the skin of Rana esculenta inhabiting in Korea.

    • Reference

    • Mol Cells. 2004 Jun 30;17(3):469-476.

    • Author

    • Won HS, Kim SS, Jung SJ, Son WS, Lee B, Lee BJ.