General Information
-
DRAMP ID
- DRAMP01932
-
Peptide Name
- Brevinin-2Ee (Frogs, amphibians, animals)
-
Source
- Rana esculenta (Edible frog) (Pelophylax esculentus)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GIFDKLKNFAKGVAQSLLNKASCKLSGQC
-
Sequence Length
- 29
-
UniProt Entry
- P40841
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
- [Swiss_Prot Entry P40841]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
-
Hemolytic Activity
-
- [Ref.8163497]LC50>100 µM against human erythrocytes
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01932.
Physicochemical Information
-
Formula
- C135H226N38O39S2
Absent Amino Acids
- EHMPRTWY
Common Amino Acids
- K
Mass
- 3069.63
PI
- 9.6
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 11
Net Charge
- +4
-
Boman Index
- -25.62
Hydrophobicity
- -0.024
Aliphatic Index
- 87.59
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.46
Polar Residues
- 10
DRAMP01932
Comments Information
Function
- Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity
Literature Information
- ·Literature 1
-
Title
- Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
-
Pubmed ID
- 8163497
-
Reference
- J Biol Chem. 1994 Apr 22;269(16):11956-11961.
-
Author
- Simmaco M, Mignogna G, Barra D, Bossa F.