General Information
-
DRAMP ID
- DRAMP01945
-
Peptide Name
- Brevinin-1SE (Frogs, amphibians, animals)
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Source
- Rana sevosa (Dusky gopher frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- FLPLVRGAAKLIPSVVCAISKRC
-
Sequence Length
- 23
-
UniProt Entry
- P85056
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli K12;
- Gram-positive bacterium: Micrococcus luteus NCT C2665.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01945.
Physicochemical Information
-
Formula
- C111H193N31O26S2
Absent Amino Acids
- DEHMNQTWY
Common Amino Acids
- ALV
Mass
- 2442.07
PI
- 10.11
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +4
-
Boman Index
- 0.89
Hydrophobicity
- 1.052
Aliphatic Index
- 135.65
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 5.68
Polar Residues
- 5
DRAMP01945
Comments Information
Mast cell degranulating peptide. Causes histamine release from rat peritoneal mast cells in vitro.
Literature Information
- ·Literature 1
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Title
- Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa.
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Pubmed ID
- 16386333
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Reference
- Peptides. 2006 Jun;27(6):1313-1319.
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Author
- Graham C, Richter SC, McClean S, O'Kane E, Flatt PR, Shaw C.