General Information

    • DRAMP ID

    • DRAMP01946

    • Peptide Name

    • Brevinin-20a (Frogs, amphibians, animals)

    • Source

    • Rana Ornativentris (Japanese mountain brown frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFNVFKGLKTAGKHVAGSLLNQLKCKVSGGC

    • Sequence Length

    • 32

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus;
      • Gram-negative bacterium: Escherichia coli.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01946 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01946.

Physicochemical Information

    • Formula

    • C146H244N42O39S2

    • Absent Amino Acids

    • DEIMPRWY

    • Common Amino Acids

    • G

    • Mass

    • 3275.92

    • PI

    • 9.9

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • -6.1

    • Hydrophobicity

    • 0.247

    • Aliphatic Index

    • 94.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.03

    • Polar Residues

    • 13

DRAMP01946

DRAMP01946 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris.

    • Reference

    • J Pept Res. 2001 Nov;58(5):349-356.

    • Author

    • Kim JB et al Conlon JM.