• • DRAMP ID

  • DRAMP01961

• • Peptide Name

  • Brevinin-1BYb (Frogs, amphibians, animals)

• • Source

  • Rana boylii (Foothill yellow-legged frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FLPILASLAAKLGPKLFCLVTKKC

• • Sequence Length

  • 24

• • UniProt Entry

  • P84112

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.14531844]Gram-positive bacterium: Staphylococcus aureus(MIC=4 µM);
    • Gram-negative bacterium: Escherichia coli(MIC=16 µM);
    • Yeast: Candida albicans(MIC=16 µM).

• • Hemolytic Activity

  • • [Ref.14531844]HC50=4 µM against human erythrocytes

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01961_predicted_structure.pdb to download.

DRAMP01961

• • Function

  • Has hemolytic activity.

• ·Literature 1

• • Title

  • Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.

• • Pubmed ID

  • 14531844

• • Reference

  • J Pept Res. 2003 Nov;62(5):207-213.

• • Author

  • Conlon JM, Sonnevend A, Patel M, Davidson C, Nielsen PF, Pál T, Rollins-Smith LA.