General Information
-
DRAMP ID
- DRAMP01976
-
Peptide Name
- Brevinin-2Eg (Frogs, amphibians, animals)
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Source
- Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- GIMDTLKNLAKTAGKGALQSLLNHASCKLSGQC
-
Sequence Length
- 33
-
UniProt Entry
- P86154
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
- [Swiss_Prot Entry P86154]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
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Hemolytic Activity
-
- [Ref.18855342]show hemolytic activity
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01976.
Physicochemical Information
-
Formula
- C142H247N43O45S3
Absent Amino Acids
- EFPRVWY
Common Amino Acids
- L
Mass
- 3372.96
PI
- 9.31
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 11
Net Charge
- +4
-
Boman Index
- -24.93
Hydrophobicity
- -0.009
Aliphatic Index
- 94.85
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.91
Polar Residues
- 13
DRAMP01976
Comments Information
Function
- Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
Literature Information
- ·Literature 1
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Title
- De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
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Pubmed ID
- 18855342
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Reference
- Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.
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Author
- Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.