• DRAMP ID

    • DRAMP01976
    • Peptide Name

    • Brevinin-2Eg (Frogs, amphibians, animals)
    • Source

    • Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GIMDTLKNLAKTAGKGALQSLLNHASCKLSGQC
    • Sequence Length

    • 33
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

    • [Swiss_Prot Entry P86154]Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species
    • Hemolytic Activity

      • [Ref.18855342]show hemolytic activity
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01976 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01976.
    • Formula

    • C142H247N43O45S3
    • Absent Amino Acids

    • EFPRVWY
    • Common Amino Acids

    • L
    • Mass

    • 3372.96
    • PI

    • 9.31
    • Basic Residues

    • 5
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +4
    • Boman Index

    • -24.93
    • Hydrophobicity

    • -0.009
    • Aliphatic Index

    • 94.85
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.91
    • Polar Residues

    • 13

DRAMP01976

DRAMP01976 chydropathy plot
    • Function

    • Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
  • ·Literature 1
    • Title

    • De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.
    • Reference

    • Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.
    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.