General Information

    • DRAMP ID

    • DRAMP01979

    • Peptide Name

    • Brevinin-2Ra (Frogs, amphibians, animals)

    • Source

    • Pelophylax ridibundus (Marsh frog) (Rana ridibunda)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GILDSLKNFAKDAAGILLKKASCKLSGQC

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01979 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01979.

Physicochemical Information

    • Formula

    • C131H226N36O39S2

    • Absent Amino Acids

    • EHMPRTVWY

    • Common Amino Acids

    • KL

    • Mass

    • 2993.57

    • PI

    • 9.24

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • -17.53

    • Hydrophobicity

    • 0.203

    • Aliphatic Index

    • 107.93

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.46

    • Polar Residues

    • 9

DRAMP01979

DRAMP01979 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide. (By similarity)

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • contains one disulfide bond 23-29.

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda.

    • Reference

    • Rapid Commun Mass Spectrom. 2008 Nov;22(22):3517-3525.

    • Author

    • Samgina TY, Artemenko KA, Gorshkov VA, Ogourtsov SV, Zubarev RA, Lebedev AT.