• • DRAMP ID

  • DRAMP01990

• • Peptide Name

  • Brevinin-1LT1 (Frogs, amphibians, animals)

• • Source

  • Hylarana latouchii (Chinese broad-folded frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FMGSALRIAAKVLPAALCQIFKKC

• • Sequence Length

  • 24

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.19340924]Gram-positive bacteria: Staphylococcus aureus (MIC=6.25 µM), Bacillus subtilis (MIC=6.25 µM);
    • Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 µM);
    • Yeast: Candida albicans (MIC=50 µM).

• • Hemolytic Activity

  • • [Ref.19340924]LC50>200 µg/ml against rabbit red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01990.

DRAMP01990

• • Function

  • Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity against rabbit red blood cells.

• ·Literature 1

• • Title

  • Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae).

• • Pubmed ID

  • 19340924

• • Reference

  • Biochimie. 2009 Apr;91(4):540-547.

• • Author

  • Wang H, Yan X, Yu H, Hu Y, Yu Z, Zheng H, Chen Z, Zhang Z, Liu J.