General Information
-
DRAMP ID
- DRAMP02017
-
Peptide Name
- Brevinin-2DYa (Frogs, amphibians, animals)
-
Source
- Rana dybowskii (Dybovsky's frog) (Korean brown frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GLLSAVKGVLKGAGKNVAGSLMDKLKCKLFGGC
-
Sequence Length
- 33
-
UniProt Entry
- P0C5X1
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC<15 µM);
- Gram-positive bacterium: Staphylococcus aureus (MIC<15 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02017.
Physicochemical Information
-
Formula
- C144H252N40O39S3
Absent Amino Acids
- EHIPQRTWY
Common Amino Acids
- G
Mass
- 3264.01
PI
- 9.79
Basic Residues
- 6
Acidic Residues
- 1
Hydrophobic Residues
- 13
Net Charge
- +5
-
Boman Index
- 6.08
Hydrophobicity
- 0.476
Aliphatic Index
- 106.36
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.91
Polar Residues
- 12
DRAMP02017
Comments Information
Function
- Antimicrobial peptide.
Tissue specificity
- Expressed by the skin glands.
PTM
- contains one disulfide bond 27-33.
Literature Information
- ·Literature 1
-
Title
- Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.
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Pubmed ID
- 17688900
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Reference
- Toxicon. 2007 Nov;50(6):746-756.
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Author
- Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.