• DRAMP ID

    • DRAMP02020
    • Peptide Name

    • Brevinin-1DYc (Frogs, amphibians, animals)
    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FLPLLLAGLPKLLCLFFKKC
    • Sequence Length

    • 20
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Swiss_Prot Entry P0C5W8]Gram-positive bacterium: Staphylococcus aureus;
      • Gram-negative bacterium: Escherichia coli (MIC<15 µM).
    • Hemolytic Activity

      • [Ref.17688900]LC50<7 μM against human erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02020 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02020.
    • Formula

    • C114H185N23O21S2
    • Absent Amino Acids

    • DEHIMNQRSTVWY
    • Common Amino Acids

    • L
    • Mass

    • 2277.98
    • PI

    • 9.39
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +3
    • Boman Index

    • 36.96
    • Hydrophobicity

    • 1.515
    • Aliphatic Index

    • 161
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.58
    • Polar Residues

    • 3

DRAMP02020

DRAMP02020 chydropathy plot
    • Function

    • Antimicrobial peptide. Has low activity against the Gram-positive bacteria
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • contains one disulfide bond 14-20.
  • ·Literature 1
    • Title

    • Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.
    • Reference

    • Toxicon. 2007 Nov;50(6):746-756.
    • Author

    • Conlon JM, Kolodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.