General Information

    • DRAMP ID

    • DRAMP02029

    • Peptide Name

    • Brevinin-1CDYd (Frogs, amphibians, animals)

    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLPLLLAGLPKLLCFLFKKC

    • Sequence Length

    • 20

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02029 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02029.

Physicochemical Information

    • Formula

    • C114H185N23O21S2

    • Absent Amino Acids

    • DEHIMNQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 2277.98

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • 36.96

    • Hydrophobicity

    • 1.515

    • Aliphatic Index

    • 161

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.58

    • Polar Residues

    • 3

DRAMP02029

DRAMP02029 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity againist Gram-negative bacteria and Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • contains one disulfide bond 14-20.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.

    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.

    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.